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#Binding

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Jonathan

SARS-CoV-2 KP.3 has greatly increased binding affinity to ACE2. This means better transmission and also less virus to do its thing in the body.

"which exhibits a huge ~10-fold KD drop in SPR experiments."

biorxiv.org/content/10.1101/20

bioRxiv · Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2The recent emergence of SARS-CoV-2 variants KP.2 and KP.3 has been marked by mutations F456L/R346T and F456L/Q493E, respectively, which significantly impact how the virus interacts with human ACE2 and its resistance to neutralizing antibodies. KP.3, featuring F456L and Q493E, exhibits a markedly enhanced ACE2 binding affinity compared to KP.2 and the JN.1 variant due to synergistic effects between these mutations. This study elucidated the structures of KP.2 and KP.3 RBD in complex with ACE2 using cryogenic electron microscopy (Cryo-EM) and deciphered the structural and thermodynamic implications of these mutations on receptor binding by molecular dynamics (MD) simulations, revealing that F456L mutation facilitates a more favorable binding environment for Q493E, leading to stronger receptor interactions which consequently enhance the potential for incorporating additional evasive mutations. These results underscore the importance of understanding mutational epistatic interactions in predicting SARS-CoV-2 evolution and optimizing vaccine updates. Continued monitoring of such epistatic effects is crucial for anticipating new dominant strains and preparing appropriate public health responses. ### Competing Interest Statement Y.C. is a co-founder of Singlomics Biopharmaceutials. Other authors declare no competing interests.
#SARSCoV2#binding#KP3
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Chuck Darwin

The latest poll shows ♦️70 percent of Republicans ♦️support a #binding #code #of #conduct for justices that would
🔸require disclosure of gifts,
🔸prohibit involvement in political activity, and
🔸mandate recusal from cases involving conflicts of interest for themselves or their spouses.

Slimmer majorities of Republicans support the #constitutional #amendment proposal (54 percent) and the #term #limits proposal (51 percent).

Total support among respondents for the ⭐️code of conduct is 76 percent,
including 89 percent of Democrats and 75 percent of independents.

For the ⭐️constitutional amendment, overall support is at 70 percent, with 89 percent of Democrats and 72 percent of independents supporting the reform.

For ⭐️term limits, 63 percent of total respondents support the reform, including 83 percent of Democrats and 61 percent of independents.

When respondents were asked whether they support the reforms, 👉they were not told Biden proposed them.👈

Offentlig
Chuck Darwin

Most REPUBLICANS support the policy proposals in President #Biden’s plan
to ⭐️reform the Supreme Court,⭐️ according to a new USA Today/Ipsos poll.

Biden outlined a three-pronged approach to reforming the high court in a speech last month,
calling for a #binding #code #of #conduct,
18-year #term #limits for Supreme Court justices,
and a Constitutional amendment declaring no one — not even the president — is #above #the #law.

thehill.com/regulation/court-b

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